Post by Carl on Nov 12, 2021 14:28:55 GMT -5
AAP Recommends our Aquarium Medications Part 2 Article.
www.americanaquariumproducts.com/AquariumMedication2.html
Here is an excerpt from the section dealing with Sulfathiazole:
Sulfas are considered all anti-bacterials (antimicrobials).
These drugs are bacteriostatic, meaning they inhibit the growth of the bacteria but do not kill them.
Sulfas are generally most effective against aerobic gram-negative organisms, and occasionally effective against anaerobic gram negative bacteria, but are not reliable against aerobic gram-positive bacterium such as Streptococcus
More on: Streptococcus Eye Infection
Sulfa drugs arrest cell growth by inhibiting the synthesis of folic acid, a component required for growth by bacteria. Folic acid is a large molecule and is unable to enter bacterial cells, so the bacteria must synthesize the compound intracellularly.
Animal cells are unable to synthesize folic acid and it must be provided in the diet. For this reason sulfa drugs are not toxic to animal cells.
Sulfa drugs are among the oldest in the medicine, the first being a sulfonamide was trade named Prontosil dating back to experiments by Bayer in 1932.
For aquatic use Sulfa are often maligned by many aquarists as not effective or out of date, yet in reality Triple Sulfa often will work where other antibiotics fail and sometimes with less side effects as well (this is not to say Sulfas do not have side effects as they are somewhat toxic, producing blood abnormalities and kidney damage when indiscriminately used).
Sulfas also do not tend to be as sensitive to poor use (meaning not following the full treatment regimen).
www.americanaquariumproducts.com/AquariumMedication2.html
Here is an excerpt from the section dealing with Sulfathiazole:
Sulfas are considered all anti-bacterials (antimicrobials).
These drugs are bacteriostatic, meaning they inhibit the growth of the bacteria but do not kill them.
Sulfas are generally most effective against aerobic gram-negative organisms, and occasionally effective against anaerobic gram negative bacteria, but are not reliable against aerobic gram-positive bacterium such as Streptococcus
More on: Streptococcus Eye Infection
Sulfa drugs arrest cell growth by inhibiting the synthesis of folic acid, a component required for growth by bacteria. Folic acid is a large molecule and is unable to enter bacterial cells, so the bacteria must synthesize the compound intracellularly.
Animal cells are unable to synthesize folic acid and it must be provided in the diet. For this reason sulfa drugs are not toxic to animal cells.
Sulfa drugs are among the oldest in the medicine, the first being a sulfonamide was trade named Prontosil dating back to experiments by Bayer in 1932.
For aquatic use Sulfa are often maligned by many aquarists as not effective or out of date, yet in reality Triple Sulfa often will work where other antibiotics fail and sometimes with less side effects as well (this is not to say Sulfas do not have side effects as they are somewhat toxic, producing blood abnormalities and kidney damage when indiscriminately used).
Sulfas also do not tend to be as sensitive to poor use (meaning not following the full treatment regimen).