Does Naladin Kill micro-sporozoan parasites?

[chinadoll1]

I have had what i have determined to be Neon tetra disease kill many guppies.  I assume they got the tiny fungi-spores from feeding them freeze dried Tubifex worms, which i have heard bad things about before, but assumed freeze dried was safe.
More research led me to find out that NTD is a common parasite.

My guppies got bent spines (random, on adults too)  and many of them lost color, and had diahreeah, quite a few died, and many stopped eating.   Many, many fry kept dying, and most had bent spines.  The amount of bent spines tells me for sure this is not genetic abnormalaties.

So i treated with naladin, and they immediately picked up.   
Once before i treated my white guppies with naladin, as i had done research and found that naladin kills NTD....

It says so on the package, and on the AAP website, does anyone have a link to a study or "proof" that naladin can kill NTD?  The fish that were fry, then juvs, were treated 2-3 times about a month apart, and they almost all grew up with straight backs.

My personal experience tells me whatever they had, it did work.  I just want to make sure those tiny little buggars dont ever come back!

[devonjohnsgard]

I'm not sure about the NTD, but I wonder about your mineral cations for the tank. Bent spines happen when there's a lack of minerals. If there's not added minerals, their immunity can be weakened and could contract NTD.

Here's more information on how to dose minerals.

Sick fish, what do I do?
www.fishbeginner.info/home/my-fish-are-sick-what-do-i-do/

Fish beginner chemistry
www.fishbeginner.info/home/aquarium-gh-kh-ph-chemistry-what-to-know/

[chinadoll1]

I live in nebraska, my water is so hard it leaves a calcium ring on the tank. I also feed a variety of foods, some of which has extra calcium.
That being said, the GH is not too crazy from what i can tell, having tested before its like 250 and the KH is somewhat low i think 100 or less.

There is a small trace of led, but i usually use prime and keep charcol and zeolite in my tanks.
Do you think ammonia or nitrite can cause it?

Im not a beginner, but i am having ongoing frequent problems with spine deformities, and i cant find the cause.  Other than sounding crazy talking about "tiny spore parasites" which actually, tubifex do harbor and i belive there is validity to my research.
There are lots of articles on tubifex worms and micro sporozoan parasites, but there are not much on naladin.


Other possible environmental causes?

[kagome]

Fish tuberculosis, Mycobacterium marinum, can cause spinal deformities. According to some sources, it's neither gram-negative or gram-positive. But then other sources say it's gram-positive.

Since Naladin attacks gram-positive bacteria, it could be that they had fish TB. I had a tiger barb that developed fish TB and had a bent spine.

www.ncbi.nlm.nih.gov/books/NBK441883/

If it is fish TB, you've got to be careful since it can become a skin infection in humans.

en.wikipedia.org/wiki/Mycobacterium_marinum

[devonjohnsgard]

That's a bit harder water, but I would still consider dosing electrolytes as harder water can have the minerals, but not be electrically charged, which is what's needed for osmoregulation and causing the curved spine.

Here's some more information about curved spines
www.aquarium-pond-answers.com/2012/04/tb-in-fish-mycobacterium-tuberculosis.html

Some info about the worms and not best to feed them.
www.aquarium-pond-answers.com/2016/03/whirling-disease-myxobolus-cerebralis.html

My experience with the curved spine is once it happens the fish has never straightened back out.

[Carl]

I’ve used Naladin many times before to treat what was suspected was NTD with success (but I also have failed, as this can be really tough, especially once advanced).
How it works on a sporozoan I am unsure, since it is primarily effective for gram negative bacterium (mostly urinary tract infections in humans)

As for Fish TB, I’ve never had success with Naladin for Fish TB.
While I have found Fish TB take a lot of treatments (often cost prohibitive for larger aquariums), it is Isoniazid that has been mst effective

Reference:
www.aquarium-pond-answers.com/2007/02/neon-tetra-disease.html
www.aquarium-pond-answers.com/2012/04/tb-in-fish-mycobacterium-tuberculosis.html